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ELAPRASE as an enzyme-replacement therapy

Hunter syndrome is caused by the deficiency of iduronate-2-sulfatase (I2S), an enzyme involved in GAG catabolism.1

ELAPRASE is a purified form of the lysosomal enzyme iduronate-2-sulfatase, which is produced in a human cell line, therefore providing a human glycosylation profile. This ensures ELAPRASE is comparable to the naturally occurring enzyme and can act as a replacement in patients with Hunter syndrome.2


  1. Martin R, Beck M, Eng C et al. Pediatrics. 2008;1221(2):e377–386.

  2. Elaprase Summary of product Characteristics. 2020.